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Pathak, A. K.
- Various Methods for Synthesis of Purine Analogues
Abstract Views :229 |
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Authors
Affiliations
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow, IN
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 9 (2011), Pagination: 1361-1365Abstract
The purine analogues are new class of nonclassical antimicrobial agents that binds with riboswitches. Purine (adenine) analogues are having antimicrobial, antifungal, antitumour, antiproliferative, antiviral and activity against HSV-1. Riboswitches are structured RNA domains that can bind directly to specific ligands and regulate gene expression. These RNA elements are located most commonly within the non-coding regions of bacterial mRNAs, because these genes were involved in fundamental metabolic pathways in certain bacterial pathogens. Purine-binding riboswitches may be targets for the development of novel antimicrobial agents. Designed compounds are bound by a purine riboswitches aptamer in vitro with affinities comparable to that of the natural ligand, and several also inhibit microbial growth.Keywords
Purines, Synthesis.- Chemistry of Fullerene and it’s Application:A Review
Abstract Views :198 |
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Authors
Affiliations
1 Saroj Institute of Technology and Management, Lucknow, U.P., IN
2 Pranveer Singh Institute of Technology, Kanpur, U.P., IN
1 Saroj Institute of Technology and Management, Lucknow, U.P., IN
2 Pranveer Singh Institute of Technology, Kanpur, U.P., IN